Institute of Biochemistry

Publications 2021

Plé, C.#, Tam, H. K.#, Vieira Da Cruz, A., Compagne, N., Jiménez-Castellanos, J. C., Müller, R. T., Pradel, E., Foong, W. E., Malloci, G.,Ballée, A., Kirchner, M. A., Moshfegh, P., Herledan, A., Herrmann A., Déprez, B., Willand, N., Vargiu, A. V., Pos K. M.*, Flipo, M.*, Hartkoorn, R. C.* (2021) Nat. Commun. accepted.

Cuesta Bernal, J., El-Delik, J., Göttig, S., Pos, K. M.* (2021) Characterization and molecular determinants for beta-lactam specificity of the multidrug efflux pump AcrD from Salmonella typhimurium Antibiotics, 10: 1494 www.mdpi.com/2079-6382/10/12/1494

Ornik-Cha, A.#, Wilhelm, J.#, Kobylka, J., Sjuts, H., Vargiu, A. V., Malloci, G., Reitz, J., Seybert, A., Frangakis, A. S.*, Pos K. M.* (2021) Structural and functional analysis of the promiscuous AcrB and AdeB efflux pumps suggests different drug binding mechanisms Nat. Commun. 12:6919
Pubmed

Sumyk, M., Himpich, S., Foong, W. E., Herrmann, A., Pos K. M., Tam, H.K. (2021) Binding of Tetracyclines to Acinetobacter baumannii TetR Involves Two Arginines as Specificity Determinants. Front. Microbiol. 12: 711158. doi: 10.3389/fmicb.2021.711158
Pubmed

Tam. H. K.*, Foong, W. E., Oswald, C., Herrmann, A., Zeng, H., Pos K. M.* (2021) Allosteric drug transport mechanism of multidrug transporter AcrB. Nat. Commun. 12: 3889 doi.org/10.1038/s41467-021-24151-3
Pubmed

Alav, I. , Kobylka, J., Kuth, M. S., Pos, K. M., Picard, M., Blair, J. M. A., Bavro, V. N. (2021). Structure, Assembly, and Function of Tripartite Efflux and Type 1 Secretion Systems in Gram-Negative Bacteria.. Chem. Rev. 121: 5479-5596
Pubmed

Publications 2020

Marine, E.*, Pos, K. M. (2020). Antimicrobial Sensitivity Assay for Bdellovibrio bacteriovorus. Bio-protoc. 10: e3865.
Pubmed

Yousefian, N., Ornik-Cha, A., Poussard, S.#, Decossas, M.#, Berbon, M., Daury, L., Taveau, J. C., Dupuy, J. W., Đorđević-Marquardt, S., Lambert, O*., Pos, K. M.* (2020) Structural characterization of the EmrAB-TolC efflux complex from E. coli. Biochim Biophys Acta Biomembr. 1863: 183488 10.1016/j.bbamem.2020.183488
Pubmed

Marine, E., Millner, D. S., Lambert, C., Sockett, R. E., Pos, K. M.* (2020) A novel method to determine antibiotic sensitivity in Bdellovibrio bacteriovorus reveals a DHFR-dependent natural trimethoprim resistance. Sci. Rep. 10: 5315 10.1038/s41598-020-62014-x
Pubmed

Foong, W. E., Wilhelm, J., Tam, H. K.#, Pos, K. M#*. (2020) Tigecycline efflux in Acinetobacter baumannii is mediated by TetA in synergy with RND-type efflux transporters. J. Antimicrob. Chemother. 10.1093/jac/dkaa015
Pubmed

Tam. H. K., Malviya, V. N., Foong, W. E., Herrmann, A., Malloci G., Ruggerone P., Vargiu A. V.*, Pos K. M.* (2020) Binding and transport of carboxylated drugs by the multidrug transporter AcrB. J. Mol. Biol. 10.1016/j.jmb.2019.12.025
Pubmed

Kobylka, J#., Kuth, M. S.#, Müller, R#. T., Geertsma, E. R., Pos, K. M.* (2020) AcrB: a mean, keen, drug efflux machine. Ann. N. Y. Acad. Sci. 1459: 38-68 10.1111/nyas.14239
Pubmed

Publications 2019

Tietgen, M., Kramer, J. S., Brunst, Djahanschiri, B., Wohra, S., Higgins, P. G., Weidensdorfer, M., Riedel-Christ, S., Pos, K. M., Gonzaga, A. Steglich, M., Nübel, U., Ebersberger, I., Proschak, E., Göttig, S. (2019) Identification of the novel class
D β-lactamase OXA-679 involved in carbapenem resistance in 
Acinetobacter calcoaceticus. J. Antimicrob. Chemother. dkz080 doi:10.1093/jac/dkz080
Pubmed

Foong, W. E., Tam, H. K., Crames, J. J., Averhoff, B., Pos, K. M.* (2019) The chloramphenicol/H+ antiporter CraA of Acinetobacter baumannii AYE reveals a broad substrate specificity. J. Antimicrob. Chemother. dkz024 doi: 10.1093/jac/dkz024
Pubmed

# = equally contributed

* = correspondi

Group Members

(For e-mail, just click on the name after "Email")

Dr. Klaas Martinus Pos
Professor & Group Leader     
phone +49-(0)69-798-29251
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Beate Braungart     
Administrative assistant
phone +49-(0)69-798-29238
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Senior Scientists

Dr. Oliver Richter     
phone +49-(0)69-798-29240
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Postdocs

Dr. Reinke Müller
phone: +49-(0)69-798-29241
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Dr. Hui Zeng
phone: +49-(0)69-798-29242
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Graduate students

Jessica Kobylka
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Miriam Schmidt
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Maryia Lazarova
Phone: +49-(0)69 - 798 29241
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Julia Wilhelm    
phone +49-(0)69-798-29241
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Technicians

Jasmin El-Delik       
phone +49-(0)69-798-29240
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Christian Groß
phone: +49-(0)69-798-29236
Email:

Andrea Herrmann
phone +49-(0)69-798-29242
Email.