General Contact

Dr. Bernd Ludwig
Professor & Group Leader






           CEF website

Molecular Genetics

The research interest of the group focusses on membrane proteins, in particular electron transport complexes of the respiratory chain, using bacteria as simple model systems. Structure/function relationships in cytochrome complexes are studied, using current methods of site-directed mutagenesis and enzyme characterization to learn about (i) redox and energy transduction properties of such enzymes and (ii) their redox cofactor insertion.

Three-dimensional structure of the Paracoccus denitrificans aa3 cytochrome c oxidase (a thin section of the lipid bilayer illustrates the membrane incorporation). Subunits I, II, III and IV are shown in green, yellow, iceblue and magenta, respectively (for details see Iwata et al., 1995).

                                              Electron transfer chain in Paracoccus denitrificans