Institute of Biochemistry

Publications 2011

Reimer, D., Pos, K. M., Thines, M., Grün, P., Bode, H.B. (2011)
A natural prodrug activation mechanism in non-ribosomal peptide synthesis.
Nature Chem. Biol, 7:  888-890

Vargiu, A. V., Collu, F., Schulz, R., Pos, K. M., Zacharias, M., Kleinekathöfer, U., Ruggerone, P. (2011)
Effect of the F610A Mutation on Substrate Extrusion in the AcrB Transporter: Explanation and Rationale by Molecular Dynamics Simulations.
J. Am. Chem. Soc. 133: 10704-10707.

Brandstätter, L., Sokolova, L., Eicher, T., Seeger, M., Briand, C., Cha, H-J., Cernescu, M., Bohnert, J., Kern, W., Brutschy, B., Pos, K.M.* (2011)
Analysis of AcrB and AcrB/DARPin ligand complexes by LILBID MS.
Biochem. Biophys. Acta, 1808: 2189-2196.

Oswald, C., Pos, K. M. (2011)
Drug resistance: A periplasmic Menage a Trois.
Chem. Biol. 18: 405-407.

Oberfeld, B., Ruffieux-Daidie, D., Vitagliano, J.J., Pos, K.M., Verrey, F., Staub, O. (2011)
Ubiquitin-specific protease 2-45 (Usp2-45) binds to epithelial Na+ channel (ENaC) ubiquitylating enzyme Nedd4-2.

Am. J. Physiol. Renal. Physiol., 2011 Apr 6th

Publications 2010

Pietras, Z., Lin, H. T., Surade, S., Luisi, B., Slattery, O., Pos, K. M., Moreno, A. (2010)
The use of novel organic gels and hydrogels in protein crystallization.
J. Appl. Cryst. 43: 58-63


Publications 2009

Pos, K. M. (2009)
Trinity revealed: Stoichiometric complex assembly of a bacterial multidrug efflux pump.
Proc Natl Acad Sci USA 106:6893-6894.

Seeger, M. A., von Ballmoos, C., Verrey, F., Pos, K. M. (2009)
Crucial Role of Asp408 in the Proton Translocation Pathway of Multidrug Transporter AcrB: Evidence from Site-Directed Mutagenesis and Carbodiimide Labeling.
Biochemistry 48: 5801-5812.

Eicher, T., Brandstätter, L., Pos, K. M. (2009)
Structural and functional aspects of the multidrug efflux pump AcrB.
Biol. Chem. 390: 693-699.

Pos, K. M. (2009)
Drug transport mechanism of the AcrB efflux pump.
Biochem. Biophys. Acta. 1794: 782-793.

Publications 2008

Seeger, M. A., Schiefner, A., Eicher, T., Verrey, F., Diederichs, K., Pos, K.M. (2008)
The AcrB efflux pump: conformational cycling and peristalsis lead to multidrug resistance.
Curr Drug Targets. 9: 729-749.

Camargo, S. M. R., Singer, D., Makrides, V., Huggel, K., Pos, K. M., Wagner, C.A., Kuba, K., Danilczyk, U., Skovby, F., Kleta, R., Penninger, J. M., Verrey, F.  (2008)
Tissue-specific amino acid transporter partners ACE2 and Collectrin differentially interact with Hartnup mutations.
Gastroenterology 136: 872-882.

Bohnert J. A., Schuster S., Seeger M.A., Fähnrich E., Pos K.M., Kern W.V (2008)
Site-Directed Mutagenesis reveals Putative Substrate Binding Residues in the Escherichia coli RND Efflux Pump AcrB.
J Bacteriol. 190: 8225–8229.

Gauntlett J. C., Gebhard, S., Keis, S., Manson J. M., Pos, K. M., Cook, G.M. (2008)
Molecular analysis of BcrR: A membrane-bound bacitracin sensor and DNA-binding protein from Enterococcus faecalis.
J. Biol. Chem. 283: 8591-8600.

Seeger, M. A., von Ballmoos, C., Eicher, T., Brandstätter, L., Verrey, F., Diederichs, K., Pos, K. M. (2008)
Engineered disulfide bonds support the functional rotation mechanism of multidrug efflux pump AcrB.
Nature Struc. Mol. Biol., 15: 199-205.

Group Members

(For e-mail, just click on the name after "Email")

Dr. Klaas Martinus Pos
Professor & Group Leader     
phone +49-(0)69-798-29251
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Beate Braungart     
Administrative assistant
phone +49-(0)69-798-29238
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Senior Scientists

Dr. Oliver Richter     
phone +49-(0)69-798-29240
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Postdocs

Dr. Reinke Müller
phone: +49-(0)69-798-29241
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Dr. Hui Zeng
phone: +49-(0)69-798-29242
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Graduate students

Jessica Kobylka
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Miriam Schmidt
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Maryia Lazarova
Phone: +49-(0)69 - 798 29241
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Julia Wilhelm    
phone +49-(0)69-798-29241
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Technicians

Jasmin El-Delik       
phone +49-(0)69-798-29240
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Christian Groß
phone: +49-(0)69-798-29236
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Andrea Herrmann
phone +49-(0)69-798-29242
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