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Institute of Biochemistry
Publications 2021


Diederichs T, Ahmad K, Burns JR, Nguyen QH, Siwy ZS, Tornow M, Coveney PV, Tampé R, Howorka S
Principles of small molecule transport through synthetic nanopores.
ACS Nano 2021, in press

Stefan E, Obexer R, Hofmann S, Vu Huu K, Huang Y, Morgner N, Suga H, Tampé R
De-novo macrocyclic peptides dissect energy coupling of a heterodimeric ABC transporter by multimode allosteric inhibition.
eLife 10 2021, e67732; doi:10.7554/eLife.67732

Joest EF, Winter C, Wesalo JS, Deiters A, Tampé R
Light-guided intrabodies for on-demand in-situ target recognition in human cells.
Chem Science 2021, 12,5787-95; doi:10.1039/D1SC01331A

Durán V, Grabski E, Hozsa C, Becker J, Yasar H, Costa B, Koller N, Lueder Y, Wiegmann B, Brandes G, Kaever V, Lehr CM, Tampé R, Förster R, Bosnjak B, Furch M, Graalmann T, Kalinke U
Fucosylated lipid nanocarriers loaded with antibiotics efficiently inhibit mycobacterial propagation in human myelid cells.
J Controlled Release 334. 2021, 201-22; doi:10.1016/j.conrel.2021Joest.04012

Barbet G, Nair-Gupta P, Schotsaert M, Yeung ST, Moretti J, Seyffer F, Metreveli G, Gardner T, Choi A, Tortorella D, Tampé R, Khanna KM, Garcia-Sastre A, Blander JM
TAP dysfunction in dendritic cells enables noncanonical cross-penetration for T cell priming.
Nat Immunol. 2021 Mar 31; doi:10.1038/s41590-021-00903-7.

Brunnberg J, Herbring V, Günther Castillo E, Krüger H, Wieneke R, Tampé R
Light control of the peptide-loading complex synchronizes antigen translocation and MHC trafficking.
Commun Biol.2021.doi: 10.1038/s42003-021-01890-z

Herrmann J, Tampé R
Die Biochemie-Studiengänge bekommen mehr Sichtbarkeit.


Diederichs T, Tampé R
Single cell-like systems reveal active unidirectional and light-controlled transport by nanomachineries.
ACS Nano.2021. doi: 10.1021/acsnano.0c10139. Online ahead of print.

Thomas C, Tampé R
MHC I assembly and peptide editing - chaperones, clients, and molecular plasticity in immunity.
Current Opinion in Immunology. 2021, 70:48-56 (PDF)

Sánchez MF, Els-Heindl S, Beck-Sickinger AG, Wieneke R, Tampé R
Photo-induced receptor confinement drives ligand-independent GPCR signaling.
Science. 2021 Feb 25: eabb7657. doi: 10.1126/science.abb7657. Online ahead of print. PMID: 33632896

deWaard AA, Verkerk T, Jongsma MLM, Hoefakker K, Sethumadhavan S, Gerke C, Bliss S, Kong X, Janssen GMC, deRu AH, Claas FHJ, Mulder A, Tampé R, vanVeelen PA, Halenius A, Spaapen RM
PAKC: A novel Panel of HLA class I Antigen presentation machinery Knockout Cells from the same genetic origin
2020,Eur J Immunol., doi: 10.1002/eji.202048599

Publications 2020

Thomas C, Tampé R
Structural and mechanistic principles of ABC transporters.
Annu Rev Biochem; doi:10.1146

Stefan E, Hofmann S, Tampé R
A single power stroke by ATP binding drives substrate translocation in a heterodimeric ABC Transporter.

eLife 2020;9:e55943 doi: 10.7554

Thomas C, Aller SG, Beis K, Carpenter EP, Chang G, Chen L, Dassa E, Dean M, Van Hoa FD, Ekiert D, Ford R, Gaudet R, Gong X, Holland IB, Huang Y, Kahne DK, Kato H, Koronakis V, Koth CM, Lee Y, Lewinson O, Lill R, Martinoia E, Murakami S, Pinkett HW, Poolman B, Rosenbaum D, Sarkadi B, Schmitt L, Schneider E, Shi Y, Shyng SL, Slotboom DJ, Tajkhorshid E, Tieleman P, Ueda K, Váradi A, Wen PC, Nieng Y, Zhang P, Zheng H, Zimmer J, Tampé R
Structural and functional diversity calls for a new classification of ABC transporters.
2020, FEBS Letters, doi: 10.1002/1873-3468.13935

Barth K, Rudolph M, Diederichs T, Prisner TF, Tampé R, Joseph B
Thermodynamic Basis for Conformational Coupling in an ATP-Binding Cassette Exporter.
J Phys Chem Lett 2020 Aug 20; doi:10.1021

Liamas E, Black RA, Mulheran PA, Tampé R, Wieneke R, Thomas ORT, Zhang ZJ
Probing fibronectin adsorption on chemically defined surfaces by means of single molecule force microscopy.
2020,Sci.Rep., doi: 10.1038/s41598-020-72617-z

Dultz G, Shimakami T, Schneider M, Murai K, Yamane D, Marion A, Zeitler TM, Stross C, Grimm C, Richter RM, Bäumer K, Yi M, Biondi RM, Zeuzem S, Tampé R, Antes I, Lange CM, Welsch C
Extended interaction networks with HCV protease NS3-4A substrates explain the lack of adaptive capability against protease inhibitors.
J Biol Chem 2020 Aug 3; doi:10.1074

Mavridis G, Arya R, Domnick A, Zoidakis J, Makridakis M, Vlahou A, Mpakali A, Lelis A, Georgiadis D, Tampé R, Papakyriakou A, Stern LJ, Stratikos E
A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1.
J Biol Chem.2020 MAR 17:jbc.RA120.012976 doi: 10.1074/jbc.RA120.012976

Khoo KK, Galleano I, Gasparri F, Wieneke R, Harms H, Poulsen MH, Chua HC, Wulf M, Tampé R, Pless SA
Chemical modification of proteins by insertion of synthetic peptides using tandem protein trans-splicing.
Nat Commun 2020;s41467 doi: 10.1038

Sagert L, Hennig F, Thomas C, Tampé R
A loop structure allows TAPBPR to exert its dual function as MHC I chaperone and peptide editor.
Elife.2020 Mar 13;9:e55326 doi: 10.7554

Brüchert S, Joest EF, Gatterdam K, Tampé R
Ultrafast in-gel detection by fluorescent super-chelator probes with HisQuick-PAGE.
CommunBiol2020 doi: 10.1038/s42003-020-0852-1

Nürenberg-Goloub E, Kratzat H, Heinemann H, Heuer A, Kötter P, Berninghausen O, Becker T, Tampé R, Beckmann R
Molecular analysis of the ribosome recycling factor ABCE1 bound to the 30S post-splitting complex.
EMBO J.2020 Feb 17:e103788 doi: 10.15252

Trowitzsch S, Tampé R
Multifunctional chaperone and quality control complexes in adaptive immunity. 
Annu Rev Biophys 2020 Jan 31 doi: 10.1146

Publications 2019

Diederichs T, Pugh G, Dorey A, Xing Y, Burns JR, Nguyen QH,Tornow M,Tampé R, Howorka S.
Synthetic protein-conductive membrane nanopores built with DNA.
Nat Commun 10, 5018 (2019) doi:10.1038/s41467-019-12639-y

Nürenberg-Goloub E, Tampé R.
Ribosome recycling in mRNA translation, quality control, and homeostasis.
Biol Chem. 2019 Oct 1. pii: /j/bchm.just-accepted/hsz-2019-0279/hsz-2019-0279.xml. doi: 10.1515/hsz-2019-0279.

Bock C, Zollmann T, Lindt KA, Tampé R, Abele R.
Peptide translocation by the lysosomal ABC transporter TAPL is regulated by coupling efficiency and activation energy.
Sci Rep. 2019 Aug 15;9(1):11884. doi: 10.1038/s41598-019-48343-6.

Hofmann S, Januliene D, Mehdipour AR, Thomas C, Stefan E, Brüchert S, Kuhn BT, Geertsma ER, Hummer G, Tampé R, Moeller A.
Conformation space of a heterodimeric ABC exporter under turnover conditions.
Nature. 2019 Jul 17. doi: 10.1038/s41586-019-1391-0.

Gouridis G, Hetzert B, Kiosze-Becker K, de Boer M, Heinemann H, Nürenberg-Goloub E, Cordes T, Tampé R.
ABCE1 Controls Ribosome Recycling by an Asymmetric Dynamic Conformational Equilibrium.
Cell Rep. 2019 Jul 16;28(3):723-734.e6. doi: 10.1016/j.celrep.2019.06.052.

Baldering TN, Dietz MS, Gatterdam K, Karathanasis C, Wieneke R, Tampé R, Heilemann M.
Synthetic and genetic dimers as quantification ruler for single-molecule counting with PALM.
Mol Biol Cell. 2019 Jun 1;30(12):1369-1376. doi: 10.1091/mbc.E18-10-0661. Epub 2019 Apr 10.

Wieneke R, Tampé R.
Multivalent Chelators for In Vivo Protein Labeling.
Angew Chem Int Ed Engl. 2019 Jun 17;58(25):8278-8290. doi: 10.1002/anie.201811293. Epub 2019 Mar 27.

Graab P, Bock C, Weiss K, Hirth A, Koller N, Braner M, Jung J, Loehr F, Tampé R, Behrends C, Abele R.
Lysosomal targeting of the ABC transporter TAPL is determined by membrane localized charged residues.
J Biol Chem. 2019 Mar 15. pii: jbc.RA118.007071. doi: 10.1074/jbc.RA118.007071.

Döring M, Blees H, Koller N, Tischer-Zimmermann S, Müsken M, Henrich F, Becker J, Grabski E, Wang J, Janssen H, Zuschratter W, Neefjes J, Klawonn F, Eiz-Vesper B, Tampé R, Kalinke U.
Modulation of TAP-dependent antigen compartmentalization during human monocyte-to-DC differentiation.
Blood Adv. 2019 Mar 26;3(6):839-850. doi:10.1182/bloodadvances.2018027268.

Thomas C,Tampé R.
MHC I chaperone complexes shaping immunity
Curr Opin Immunol. 2019 Jun;58:9-15. doi: 10.1016/j.coi.2019.01.001. Epub 2019 Feb 14.

Braner M, Koller N, Knauer J, Herbring V, Hank S, Wieneke R, Tampé R. 
Optical control of the antigen translocation by synthetic photo-conditional viral inhibitors.
Chem Sci. 2018 Dec 17;10(7):2001-2005. doi: 10.1039/c8sc04863k. eCollection 2019 Feb 21.

Gerovac M, Tampé R.
Control of mRNA Translation by Versatile ATP-Driven Machines.
Trends Biochem Sci. 2019 Feb;44(2):167-180. doi: 10.1016/j.tibs.2018.11.003. Epub 2018 Dec 7.