Publications 2017

Blees A, Januliene D, Hofmann T, Koller N, Schmidt C, Trowitzsch S, Moeller A, Tampé R.
Structure of the human MHC-I peptide-loading complex.
Nature. 2017 Nov 6. doi: 10.1038/nature24627.
News & Views

             Ploegh H
             Machinery that guides immunity.
             Nature. 2017 Nov 23;551(7681):442-443.
Insights & Perspective
  Lamers M, Berlin I, Neefjes J.
             Antigen Presentation: Visualizing the MHC Class I Peptide-Loading
Curr Biol. 2018 Jan 22;28(2):R83-R86. doi: 10.1016/j.cub.2017.11.059.

Thomas C, Tampé R.
Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing.
Science. 2017 Oct 12. pii: eaao6001. doi: 10.1126/science.aao6001.
News & Views

             Cresswell P
             Editing peptide presentation to T cells.
             Science. 2017 Nov 24;358(6366):992-993.

Khageh Hosseini S, Kolterer S, Steiner M, von Manstein V, Gerlach K, Trojan J, Waidmann O, Zeuzem S, Schulze JO, Hahn S, Steinhilber D, Gatterdam V, Tampé R, Biondi RM, Proschak E, Zörnig M.
Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.
Biochem Pharmacol. 2017 Oct 13. pii: S0006-2952(17)30633-0. doi: 10.1016/j.bcp.2017.10.003.

Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3.

Kankate L, Aguf A, Grossmann H, Schnietz M, Tampé R, Turchanin A, Gölzhäuser A.
Vapor phase exchange of self-assembled monolayers for engineering of biofunctional surfaces.
Langmuir. 2017 Mar 24. doi: 10.1021/acs.langmuir.6b04207. [Epub ahead of print]

Thomas C, Tampé R.
Proofreading of Peptide—MHC Complexes through Dynamic Multivalent Interactions
Front Immunol. 2017 Feb 8;8:65. doi: 10.3389/fimmu.2017.00065. Review.
PMID: 28228754


Lehnert E, Tampé R.
Structure and Dynamics of Antigenic Peptides in Complex with TAP
Front. Immunol., 30 January 2017

Nöll A, Thomas C, Herbring V, Zollmann T, Barth K, Mehdipour AR, Tomasiak TM, Brüchert S, Joseph B, Abele R, Oliéric V, Wang M, Diederichs K, Hummer G, Stroud RM, Pos KM, Tampé R.
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.
Proc Natl Acad Sci U S A. 2017 Jan 9. pii: 201620009. doi: 10.1073/pnas.1620009114. [Epub ahead of print]

Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P.
Mutual A domain interactions in the force sensing protein von Willebrand factor.

J Struct Biol 2017 197, 57-64.

Braner M, Wieneke R and Tampé R.
Nanomolar Affinity Protein Trans-Splicing Monitored in Real-Time
by Fluorophore-Quencher Pairs

Chem. Commun., 2017, 545-8. DOI: 10.1039/C6CC08862G.

Publications 2016

Herbring V, Bäucker A,Trowitzsch S, Tampé R
A dual inhibition mechanism of herpesviral ICP47 arresting a conformationally thermostable TAP complex
Scientific Reports 6, 36907

Kiosze-Becker K, Ori A, Gerovac M, Heuer A, Nürenberg-Goloub E, Jan Rashid U,
Becker T, Beckmann R, Beck M, Tampé R,
Structure of the ribosome post-recycling complex probed by chemical cross-linking and mass spectrometry
Nature Communications 2016/11/08/online

Robb NC, Te Velthuis AJ, Wieneke R, Tampé R, Cordes T, Fodor E, Kapanidis AN.
Single-molecule FRET reveals the pre-initiation and initiation conformations of influenza virus promoter RNA.
Nucleic Acids Res. 2016 Sep 30. pii: gkw884.

Lehnert E, Mao J, Mehdipour AR, Hummer G, Abele R, Glaubitz C, Tampé R.
Antigenic peptide recognition on the human ABC transporter TAP resolved by DNP-enhanced solid-state NMR spectroscopy.
J Am Chem Soc. 2016 Sep 23. [Epub ahead of print]

Guesdon A, Bazile F, Buey RM, Mohan R, Monier S, García RR, Angevin M, Heichette C, Wieneke R, Tampé R, Duchesne L, Akhmanova A, Steinmetz MO, Chrétien D.
EB1 interacts with outwardly curved and straight regions of the microtubule lattice.
Nat Cell Biol. 2016 Oct;18(10):1102-8. doi: 10.1038/ncb3412.[Epub ahead of print]

Casanas, A, Warshamanage, R, Finke, A D, Panepucci, E, Olieric, V, Noll, A, Tampe, R, Brandstetter, S, Forster, A, Mueller, M, Schulze-Briese, C, Bunk, O & Wang, M.
EIGER detector: application in macromolecular crystallography
Acta Crystallographica Section D 2016;72(9):1036-1048doi:10.1107/S2059798316012304

Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P.
Single molecule force spectroscopy data and BD- and MD simulations on the blood protein von Willebrand factor.
Data Brief. 2016 Jul 21;8:1080-7. doi: 10.1016/j.dib.2016.07.031. eCollection 2016.

Michael Urban, Marc Vor der Brüggen, Robert Tampé.
Membrane Transport Processes Analyzed by a Highly Parallel Nanopore Chip Systemat Single Protein Resolution
J Vis Exp. 2016 Aug 16;(114). doi: 10.3791/53373.

Schmidt A, Brettschneider K, Kahle J, Orlowski A, Becker-Peters K, Stichel D, Schulze J, Braner M, Tampé R, Schwabe D, Königs C.
Neutralisation of factor VIII inhibitors by anti-idiotypes isolated from phage-displayed libraries.
Thromb Haemost. 2016 Mar 24;116(1). [Epub ahead of print]

Braner M, Kollmannsperger A, Wieneke R and Tampé R. 
‘Traceless’ tracing of proteins – high-affinity trans-splicing directed by a minimal interaction pair
Chem. Sci., 2016, 7, 2646-2652 DOI: 10.1039/C5SC02936H

Kollmannsperger A, Sharei A, Raulf A, Heilemann M, Langer R, Jensen KF, Wieneke R, Tampé R.
Live-cell protein labelling with nanometre precision by cell squeezing.
Nat Commun. 2016 Jan 29;7:10372. doi: 10.1038/ncomms10372.

Fisette O, Wingbermühle S, Tampé R, Schäfer LV.
Molecular mechanism of peptide editing in the tapasin-MHC I complex.
Sci Rep. 2016 Jan 12;6:19085. doi: 10.1038/srep19085.

Heise R, Amann PM, Ensslen S, Marquardt Y, Czaja K, Joussen S, Beer D, Abele R, Plewnia G, Tampé R, Merk HF, Hermanns HM, Baron JM.
Interferon Alpha Signalling and Its Relevance for the Upregulatory Effect of Transporter Proteins Associated with Antigen Processing (TAP) in Patients with Malignant Melanoma.
PLoS One. 2016 Jan 6;11(1):e0146325. doi: 10.1371/journal.pone.0146325. eCollection 2016.