COVER STORYS
Publications 2018

Bock C, Löhr F, Tumulka F, Reichel K, Würz J, Hummer G, Schäfer L, Tampé R, Joseph B, Bernhard F, Dötsch V,  Abele R.
Structural and functional insights into the interaction and targeting hub TMD0 of the polypeptide transporter TAPL
Scientific Reports 8, Article number: 15662 (2018)
PDF

Klein A, Hank S, Raulf A, Joest EF, Tissen F, Heilemann M, Wieneke R, Tampé R.
Live-cell labeling of endogenous proteins with nanometer precision by transduced nanobodies
Chem Sci, 9, 7835 (Edge Article) DOI: 10.1039/C8SC02910E
PDF

Glembockyte V, Wieneke R, Gatterdam K, Gidi Y, Tampé R, Cosa G.
Tris -N-Nitrilotriacetic Acid Fluorophore as a Self-Healing Dye for Single-Molecule Fluorescence Imaging.
J Am Chem Soc. 2018 Aug 23. doi: 10.1021/jacs.8b04681.
PDF

Trowitzsch S, Tampé R.
ABC Transporters in Dynamic Macromolecular Assemblies.
J Mol Biol. 2018 Aug 5. pii: S0022-2836(18)30893-3. doi: 10.1016/j.jmb.2018.07.028.
PDF

Brzozowska E, Leśniewski A, Sęk S, Wieneke R, Tampé R, Górska S, Jönsson-Niedziółka M, Niedziółka-Jönsson J.
Interactions of bacteriophage T4 adhesin with selected lipopolysaccharides studied using atomic force microscopy.
Sci Rep. 2018 Jul 19;8(1):10935. doi: 10.1038/s41598-018-29383-w.
PDF

Elina Nürenberg-Goloub, Holger Heinemann, Milan Gerovac, Robert Tampé. 
Ribosome recycling is coordinated by processive events in two asymmetric ATP sites of ABCE1
Life Science Alliance, 14 June 2018. DOI: 10.26508/lsa.20180009
PDF

Gatterdam K, Joest EF, Gatterdam V, Tampé R.
Scaffold design of trivalent chelator heads dictates high-affinity and stable His-tagged protein labeling in vitro and in cellulo.
Angew Chem Int Ed Engl. 2018 May 29. doi: 10.1002/anie.201802746. [Epub ahead of print]
PDF

Abele R and Tampé R
Moving the Cellular Peptidome by Transporters
Front. Cell Dev. Biol., 30 April 2018 | https://doi.org/10.3389/fcell.2018.00043
PDF

Diederichs T, Nguyen QH, Urban M, Tampé R, Tornow M.
Transparent Nanopore Cavity Arrays Enable Highly Parallelized Optical Studies of Single Membrane Proteins on Chip.
Nano Lett. 2018 Jun 13;18(6):3901-3910. doi: 10.1021/acs.nanolett.8b01252.
PDF

Thomas C, Tampé R.
Multifaceted structures and mechanisms of ABC transport systems in health and disease
Curr Opin Struct Biol. 2018 Apr 7;51:116-128. doi: 10.1016/j.sbi.2018.03.016.
PDF

Posch S, Obser T, König G, Schneppenheim R, Tampé R, Hinterdorfer P.
Interaction of von Willebrand factor domains with collagen investigated by single molecule force spectroscopy.
Curr Opin Struct Biol. 2018 Apr 7;51:116-128. doi: 10.1016/j.sbi.2018.03.016.
PDF

Venkataramani V, Kardorff M, Herrmannsdörfer F, Wieneke R, Klein A, Tampé R, Heilemann M Kuner T.
Enhanced labeling density and whole-cell 3D dSTORM imaging by repetitive labeling of target proteins.
Sci Rep. 2018 Apr 3;8(1):5507. doi: 10.1038/s41598-018-23818-0.
PDF

Gatterdam K, Joest EF, Dietz MS, Heilemann M, Tampé R.
Super-chelators for advanced protein labeling in living cells
Authors

Accepted manuscript online: 20 February 2018Full publication history DOI: 10.1002/anie.201800827
PDF

Barth K, Hank S, Spindler PE, Prisner TF, Tampé R, Joseph B.
Conformational Coupling and trans-Inhibition in the Human Antigen Transporter Ortholog TmrAB Resolved with Dipolar EPR Spectroscopy.
J Am Chem Soc. 2018 Jan 30. doi: 10.1021/jacs.7b12409. [Epub ahead of print]
PDF

Bartelt SM , Chervyachkova E , Steinkühler J , Ricken J , Wieneke R , Tampé R , Dimova R , Wegner SV .
Dynamic blue light-switchable protein patterns on giant unilamellar vesicles.
Chem Commun (Camb). 2018 Jan 23;54(8):948-951. doi: 10.1039/c7cc08758f.
PDF

Publications 2017

Blees A, Januliene D, Hofmann T, Koller N, Schmidt C, Trowitzsch S, Moeller A, Tampé R.
Structure of the human MHC-I peptide-loading complex.
Nature. 2017 Nov 6. doi: 10.1038/nature24627.
PDF
News & Views

             Ploegh H
             Machinery that guides immunity.
             Nature. 2017 Nov 23;551(7681):442-443.
Insights & Perspective
           
  Lamers M, Berlin I, Neefjes J.
             Antigen Presentation: Visualizing the MHC Class I Peptide-Loading
             Bottleneck.
            
Curr Biol. 2018 Jan 22;28(2):R83-R86. doi: 10.1016/j.cub.2017.11.059.

Thomas C, Tampé R.
Structure of the TAPBPR-MHC I complex defines the mechanism of peptide loading and editing.
Science. 2017 Oct 12. pii: eaao6001. doi: 10.1126/science.aao6001.
PDF
News & Views

             Cresswell P
             Editing peptide presentation to T cells.
             Science. 2017 Nov 24;358(6366):992-993.

Khageh Hosseini S, Kolterer S, Steiner M, von Manstein V, Gerlach K, Trojan J, Waidmann O, Zeuzem S, Schulze JO, Hahn S, Steinhilber D, Gatterdam V, Tampé R, Biondi RM, Proschak E, Zörnig M.
Camptothecin and its analog SN-38, the active metabolite of irinotecan, inhibit binding of the transcriptional regulator and oncoprotein FUBP1 to its DNA target sequence FUSE.
Biochem Pharmacol. 2017 Oct 13. pii: S0006-2952(17)30633-0. doi: 10.1016/j.bcp.2017.10.003.
PDF

Heuer A, Gerovac M, Schmidt C, Trowitzsch S, Preis A, Kötter P, Berninghausen O, Becker T, Beckmann R, Tampé R.
Structure of the 40S-ABCE1 post-splitting complex in ribosome recycling and translation initiation.
Nat Struct Mol Biol. 2017 May;24(5):453-460. doi: 10.1038/nsmb.3396. Epub 2017 Apr 3.
PDF

Kankate L, Aguf A, Grossmann H, Schnietz M, Tampé R, Turchanin A, Gölzhäuser A.
Vapor phase exchange of self-assembled monolayers for engineering of biofunctional surfaces.
Langmuir. 2017 Mar 24. doi: 10.1021/acs.langmuir.6b04207. [Epub ahead of print]
PDF

Thomas C, Tampé R.
Proofreading of Peptide—MHC Complexes through Dynamic Multivalent Interactions
Front Immunol. 2017 Feb 8;8:65. doi: 10.3389/fimmu.2017.00065. Review.
PMID: 28228754

PDF

Lehnert E, Tampé R.
Structure and Dynamics of Antigenic Peptides in Complex with TAP
Front. Immunol., 30 January 2017 https://doi.org/10.3389/fimmu.2017.00010
PDF

Nöll A, Thomas C, Herbring V, Zollmann T, Barth K, Mehdipour AR, Tomasiak TM, Brüchert S, Joseph B, Abele R, Oliéric V, Wang M, Diederichs K, Hummer G, Stroud RM, Pos KM, Tampé R.
Crystal structure and mechanistic basis of a functional homolog of the antigen transporter TAP.
Proc Natl Acad Sci U S A. 2017 Jan 9. pii: 201620009. doi: 10.1073/pnas.1620009114. [Epub ahead of print]
PDF

Posch S, Aponte-Santamaría C, Schwarzl R, Karner A, Radtke M, Gräter F, Obser T, König G, Brehm MA, Gruber HJ, Netz RR, Baldauf C, Schneppenheim R, Tampé R, Hinterdorfer P.
Mutual A domain interactions in the force sensing protein von Willebrand factor.

J Struct Biol 2017 197, 57-64. http://dx.doi.org/10.1016/j.jsb.2016.04.012
PDF

Braner M, Wieneke R and Tampé R.
Nanomolar Affinity Protein Trans-Splicing Monitored in Real-Time
by Fluorophore-Quencher Pairs

Chem. Commun., 2017, 545-8. DOI: 10.1039/C6CC08862G.
PDF