Group Members

Dr. Alexander Gottschalk
Professor & Group Leader     
phone +49-(0)69-798-42518 fax +49-(0)69-798-763-42518

Dr. Jana Liewald        
Postdoctoral Fellow
phone +49-(0)69-798-42513

Dr. Christina Schüler      
Postdoctoral Fellow
phone +49-(0)69-798-42520

Dr. Holger Dill    
Postdoctoral Fellow
phone +49-(0)69-798-42519

Barbara Jánosi       
PhD Student    
phone +49-(0)69-798-42519

Jonas Weil     
PhD Student
phone +49-(0)69-798-42713 

Frank Becker     
PhD Student
phone +49-(0)69-798-42519

Thilo Henß     
PhD Student
phone +49-(0)69-798-42519

Marcial Engel    
PhD Student
phone +49-(0)69-798-42713

Maximilian Bach    
PhD Student
phone +49-(0)69-798-42519

Amelie Bergs   
PhD Student
phone +49-(0)69-798-42713

Martin Schneider   
PhD Student
phone +49-(0)69-798-42519

Publications 2013

de Bono M, Schafer WR, Gottschalk A. (2013) Optogenetic actuation, inhibition, modulation and readout for neuronal networks generating behavior in the nematode Caenorhabditis elegans. In "Optogenetics"; Hegemann P, Sigrist S (editors), De Gruyter, Dahlem Workshop Reports, in press

Kittelmann M, Liewald JF, Hegermann J, Schultheis C, Brauner M, Steuer Costa W, Wabnig S, Eimer S, and Gottschalk A.  (2013) In vivo synaptic recovery following optogenetic hyperstimulation. PNAS early edition, Jul. 22, 2013

Smith CJ, O’Brien T, Chatzigeorgiou M, Spencer WC, Feingold-Link E, Husson SJ, Hori S, Mitani S, Gottschalk A, Schafer WR, Miller DM. (2013) Sensory Neuron Fates Are Distinguished by a Transcriptional Switch that Regulates Dendrite Branch Stabilization. Neuron 79: 266–280

Husson SJ, Gottschalk A and Leifer AM. (2013) Optogenetic manipulation of neural activity in C. elegans: from synapse to circuits and behavior. Biology of the Cell 105(6): 235-50

Akerboom, J, Carreras Calderon N, Tian L, Wabnig S, Prigge M, Tolö J, Gordus A, Orger MB, Severi KE, Macklin JJ, Patel R, Pulver SR, Wardill TJ, Fischer E, Schüler C, Chen T-W, Sarkisyan, KS, Marvin JS, Bargmann, CI, Kim DK, Kügler S, Lagnado L, Hegemann P, Gottschalk A, Schreiter ER and Looger LL. (2013) Genetically encoded calcium indicators for multi-color neural activity imaging in combination with optogenetics. Frontiers in Molecular Neuroscience Feb. 11, online

Publications 2012

Sasidharan N, Sumakovic M, Hannemann M, Hegermann J, Liewald JF, Olendrowitz C, Koenig S, Grant BD, Rizzoli SO, Gottschalk A and Eimer S. (2012) RAB5 and RAB10 cooperate to regulate neuropeptide release in Caenorhabditis elegans. PNAS 109: 18944-9

Erbguth K, Prigge M, Schneider F, Hegemann P and Gottschalk A. (2012)           Bimodal activation of different neuron classes with the spectrally red-shifted Channelrhodopsin chimera C1V1 in Caenorhabditis elegansPLoS ONE 7: e46827

Schmitt C, Schultheis C, Pokala N, Husson SJ, Liewald JF, Bargmann, CI and Gottschalk A. (2012) Specific expression of Channelrhodopsin-2 in single neurons of Caenorhabditis elegans. PLoS ONE 7: e43164

Brieke C, Rohrbach F, Gottschalk A, Mayer G and Heckel A. (2012)
Light controlled tools.
Angew. Chem. Int. Ed. 51: 8446-8476

Husson S, Steuer Costa W, Schmitt C and Gottschalk A. (2012)
Keeping track of worm trackers.

Husson SJ, Liewald JF, Schultheis C, Stirman JN, Lu H and Gottschalk A. (2012)     Microbial light-activatable proton pumps as neuronal inhibitors to functionally dissect neuronal networks in C. elegans. PLoS ONE 7: e40937

Husson S, Steuer Costa W, Wabnig S, Stirman JN, Watson JD, Spencer WC, Akerboom J, Looger LL, Treinin M, Miller III DM, Lu H and Gottschalk A. (2012)
Optogenetic analysis of a nociceptor neuron and network reveals ion channels acting downstream of primary sensors.
Current Biology 22: 743-752.

Stirman J, Crane M, Husson S, Gottschalk A and Lu H. (2012) 
A multispectral optical illumination system with precise spatiotemporal control for the manipulation of optogenetic reagents
Nature Protocols 7: 207-220.

Publications 2011

Vidal-Gadea A, Topper S, Young L, Crisp A, Kressin L, Elbel E, Maples T, Brauner M, Erbguth K, Axelrod A, Gottschalk A, Siegel D, Pierce-Shimomura J. (2011)
C. elegans selects distinct crawling and swimming gaits via dopamine and serotonin

PNAS 108: 17504-17509.

Schultheis C, Brauner M, Liewald JF, Gottschalk A.
Optogenetic analysis of GABAB receptor signalling in Caenorhabditis elegans motor neurons.
J Neurophysiol 2011 Aug; 106: 817-827. Epub 2011 May 25.

Schultheis C, Liewald JF, Bamberg, E, Nagel G, Gottschalk A.
Optogenetic long-term manipulation of behavior and animal development.
PLoS One 2011 April 20; 6(4): e18766.

Stirman J, Crane M, Husson S, Wabnig S, Schultheis C, Gottschalk A*, Lu H*.  (*corresponding authors)
Real-time multimodal optical control of neurons and muscles in freely behaving Caenorhabditis elegans.
Nat Methods. 2011 Feb; 8 (2):153-8. Epub 2011 Jan 16.

Weissenberger S, Schultheis C, Liewald J, Erbguth K, Nagel G, Gottschalk A.
PACα - an optogenetic tool for in vivo manipulation of cellular cAMP levels, neurotransmitter release, and behavior in Caenorhabditis elegans.
J Neurochem. 2011 Feb;116(4):616-25. doi: 10.1111/j.1471-4159.2010.07148.x. Epub 2011 Jan 20.

Publications 2010

Stirman J, Brauner M, Gottschalk A, Lu H.
High-throughput study of synaptic transmission at the neuromuscular junction enabled by optogenetics and microfluidics.
J Neurosci Meth. 2010 Aug 15;191(1):90-3. Epub 2010 Jun 9.