Dr. Robert Ernst
Juniorprofessor for Biochemistry
BMLS - office 3.670
Max-von-Laue Str. 15
phone +49-69-798 42 524
fax +49-69-798-763 42 524
KING NEWS ***BREAKING
18.10.2016: Our manuscript 'Control of membrane fluidity: The OLE pathway in focus' has been accepted for publication by Biological Chemistry. Congratulations, Stephanie!
The article summarizes our current understanding of the OLE pathway from S. cerevisiae, representing the best-studied, eukaryotic sense-and-control system regulating membrane lipid saturation. We critically discuss seemingly conflicting observations, indicate possible pitfalls, and outline future directions of research.
24.8.2016: Our manuscript 'Homeoviscous adaptation and the regulation of membrane lipids' has now appeared online and was published by the Journal of Molecular Biology (JMB). Our paper is a product of an inspiring collaboration with Bruno Antonny (Université Nice Sophia Antipolis and CNRS) and our friend Christer Ejsing (University of Southern Denmark).
***BREAKING NEWS ***
Molecular Membrane Biology - Sensing and Signaling
Biological membranes are composed of thousands of interacting proteins and lipids. In fact, membrane proteins and lipids have co-evolved since the origin of life. Owing to their complex composition, biological membranes are extremely challenging to study. Our central interest is the crosstalk of lipids and proteins for the homeostasis of biological membranes. Which molecular events are underlying lipid induced cellular stress responses? Do, for example, lipids modulate general protein degradation? To address such questions appropriately, the lab follows a strictly interdisciplinary approach, combining biochemistry, biophysics and cell biology.
Saturated and unsaturated fatty acids have gained a celebrity status and are referred to as ‘bad’ and ‘good’ fats. It is well established that a continuous misbalance of these dietary fats induces massive cellular stress responses that can ultimately result in cell death. Until now, the molecular events underlying these phenomena are not understood. With quantitative lipidomics coming of age, membrane biochemistry is gaining a new focus. Now is the time to address fundamental questions regarding membrane complexity and function.